Postdoctoral position. Bioorthogonal Chemistry
- Leioa, Vizcaya
- Temporal
- Tiempo completo
The research will focus on the development of bioorthogonal strategies to label membrane receptors in vivo. We aim to use ligand directed receptor covalent labelling, followed by biorthoogonal binding with suitably modified probes. Target receptors will be located at the neural membrane and could be AMPAR or TRP type, among others. We look for the combination of different strategies particularly those based on SuFEx reactions and those based on the reaction of tetrazines with trans-cyclooctene. The researcher will have to develop novel molecules to achieve the successful receptor labelling and the bioorthogonal binding with the selected probe, hence a deep knowledge of organic chemistry and/or medicinal chemistry is required. Background in bioorthogonal reactions will also be valued. The research is part of a collaborative interdisciplinary project that aims to neuromodulate the neuronal response.The maximum duration of the contract will be until December 2025 and the gross annual salary will be adjusted to the experience of the candidate, starting at a minimum of 31,250 euros.Required backgroundWe seek highly qualified applicants with a PhD in organic, medicinal or pharmaceutical chemistry.
Good written and oral communication in English is required.We are an equal opportunity employer committed to diversity. Applications should be addressed through the Biofisika website contact page ( ), adding the following subject: [Job Application: 120_MCarril]. It is recommended that applications are made as soon as possible as they will be considered upon arrival. Applications in a single pdf file must include:
- Curriculum Vitae.
- A motivation letter.
- The contact of 2 referees
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